Discovery, development and preclinical testing of novel markers (that may be derived from patient samples) and technologies for use in detection, diagnosis, prediction, prognosis and monitoring including:

• biological and psychological markers
• diagnostic and monitoring devices, imaging, scanning, predictive and diagnostic tests
• development and characterisation of models
• diagnostic measures and methodologies

Testing and evaluation of markers and technologies in humans for use in detection, diagnosis, prediction, prognosis and monitoring in clinical, community or applied settings including:

• assessment of sensitivity, efficacy, specificity, predictive and prognostic value, reproducibility and safety
• medical devices, imaging, diagnostic and predictive tests
• evaluation of diagnostic models, methods and methodologies in clinical or applied settings

Studies investigating impact of screening and factors affecting uptake including:

• attitudes and beliefs including cultural and religious practices
• issues relating to gender, age and ethnicity
• genetic counselling and decision making
• psychological, social and economic factors
• development, implementation and evaluation of interventions to promote screening including policy, education and communication

Studies investigating population screening programmes including:

• feasibility studies, pilot studies and trials
• evaluation of effectiveness, benefits and economic evaluation
• impact on health services and policy issues
• models of population surveillance

Development and/or distribution of resources for use by the research community including:

• equipment, cell lines, tissue and DNA banks, and informatics systems
• infrastructure support for research trials, networks, consortia and centres