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UKCRC Health Research Classification System

6.4 Surgery

Main inclusion criteria

Clinical and applied application and evaluation of surgical, obstetric and dental interventions in humans including:

  • small scale and pilot studies
  • phase I, II, III and IV trials
  • procedures including organ and bone marrow transplantation, tissue grafts and transfusions
  • monitoring outcomes, side effects and rejection

 

Advice on research activities

Includes invasive mechanical procedures.
 

Official terminology

Full name of code

Short name Unique ID
6.4 Surgery 6.4 Surgery

HRCS_RA_6_4

 

Related external links

Common Scientific Outline (CSO) – 5.2 Localised Therapies – Clinical Applications
 

Main inclusion criteria

Clinical application and evaluation of cellular, tissue and gene therapies in humans including:

  • small scale and pilot studies
  • phase I, II, III and IV trials
  • gene therapy, stem cell therapy, in vitro fertilisation, tissue engineering
  • evaluation of applied delivery systems

 

Advice on research activities

This code is suitable for studies involving stem cell therapies, particularly tissue regeneration or repair of damaged tissue, in clinical and applied settings.

Cell therapy can often involve a transplantation process but they should not be coded as 6.4 Surgery too. An exception to this is surgical transplantation of bone marrow stem cells for cancer treatment, which is considered a similar process to organ transplantation, and should therefore be coded as 6.4 Surgery.

Excludes basic developmental biology of stem cell fate which should be coded as 1.1 Biological.
 

Official terminology

Full name of code

Short name Unique ID
6.2 Cellular and gene therapies 6.2 Cell and gene therapy

HRCS_RA_6_2

 

Related external links

Common Scientific Outline (CSO) – 5.4 Systemic Therapies – Clinical Applications
 

Advice on research activities

The Surgery categories 5.4 Surgery and 6.4 Surgery include invasive mechanical procedures such as angioplasty and catheterisation.

 

Main inclusion criteria

Development of surgical, obstetric and dental interventions including:

  • histocompatability, transfusions, transplantations including xenograft studies and bone marrow transplants
  • mechanisms of recovery, tolerance, rejection and side effects including infection
  • testing in in vitro and in vivo model systems

 

Advice on research activities

Includes obstetrics and dental research and tissue grafts, whole organ or bone marrow transplants.

Includes all aspects of research related to development of surgery and surgical procedures.

Includes studies on understanding transplant tolerance and rejection.

Includes invasive mechanical procedures.

Excludes cell grafts, cell transplants and cell therapies which will involve transplantation but should only be coded as 5.2 Cellular and gene therapies.
 

Official terminology

Full name of code

Short name Unique ID
5.4 Surgery 5.4 Surgery

HRCS_RA_5_4

 

Related external links

Common Scientific Outline (CSO) – 5.1 Localised Therapies – Discovery and Development
 

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