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UKCRC Health Research Classification System

Thromboses and embolisms

Advice on health categories

In general clotting disorders should be coded as Blood; this includes deep vein thromboses (DVTs) and venous embolisms.

Diseases of the vasculature such as thrombophlebitis should be coded as Cardiovascular.

It may be appropriate to code for both Blood and Cardiovascular where the study overlaps both areas.

While general studies of clotting and thromboses should be coded as Blood, research involving blood flow to brain should be coded as Stroke. Therefore ischaemic stroke will generally be coded as 100% Stroke unless there is a clear pre-existing condition, in which case the guidance on sequelae should be followed.
 

Main inclusion criteria

Includes both ischaemic stroke (caused by blood clots) and haemorrhagic stroke (caused by cerebral/intercranial haemorrhage).
 

Advice on health categories

When coding research involving circulation or blood flow, only studies investigating blood flow to the brain should be coded as Stroke.

While general blood circulation and cardiovascular disease research should be coded as Cardiovascular, research involving blood flow to brain should be coded as Stroke. Therefore haemorrhagic stroke will generally be coded as 100% Stroke unless there is a clear pre-existing condition, in which case the guidance on sequelae should be followed:

e.g. Research on stroke resulting from brain haemorrhage should be coded as 100% Stroke.

e.g. Research on stroke as the direct result of pre-existing circulatory disorder should be coded as 50% Cardiovascular and 50% Stroke.

While general studies of clotting and thromboses should be coded as Blood, research involving blood flow to brain should be coded as Stroke. Therefore ischaemic stroke will generally be coded as 100% Stroke unless there is a clear pre-existing condition, in which case the guidance on sequelae should be followed:

e.g. Research on stroke resulting from thrombosis should be coded as 100% Stroke.

e.g. Research on stroke as the direct result of pre-existing clotting disorder should be coded as 50% Blood and 50% Stroke.

Similarly, research on symptoms of stroke on stroke survivors should also be coded as Stroke.  However, the specific symptoms (e.g. behavioural changes, mobility issues, further circulatory problems) and interventions used to treat them may be applicable to other health categories too. Use the guidance on case studies and/or sequelae to assess whether alternative or additional coding is required.
 

Official terminology

Full name of category

Short name Unique ID
Stroke Stroke

HRCS_HC_19STR

 

Related external links

International Classification of Diseases (ICD 10 v2016) – Chapter IX:   Diseases of the circulatory system (I00-I99)
 

Main inclusion criteria

Coronary heart disease, diseases of the vasculature and circulation including the lymphatic system, and normal development and function of the cardiovascular system.

 

Advice on health categories

Includes general circulation research, vasculitis and general angiogenesis studies. Includes atherosclerosis and pulmonary hypertension. Includes congenital heart disorders. Excludes studies investigating blood flow to the brain which should be coded as Stroke. Excludes angiogenesis studies which relate to a diseased state (e.g. development of anti-angiogenic drugs to inhibit tumour growth which would be coded as Cancer).

 

Official terminology

Full name of category Short name Unique ID
Cardiovascular Cardio HRCS_HC_03CAR

 

Related external links

International Classification of Diseases (ICD 10 v2016) – Chapter IX: Diseases of the circulatory system (I00-I99)

Main inclusion criteria

Haematological diseases, anaemia, clotting (including thromboses and venous embolisms) and normal development and function of platelets and erythrocytes

 

Advice on health categories

Not all haemopoietic cells or ‘blood cells’ are erythrocytes (red blood cells). This term is often used to encompass lymphocytes, macrophages, granulocytes and other white cell types. Check the context of the research.

e.g. if the research relates to leukaemia it will be referring to lymphocytes etc. and not to erythrocytes and therefore should be coded as Cancer and not be coded as Blood.

Studies investigating blood flow to the brain should be coded as Stroke.

Blood clots (thromboses) can lead to wider cardiovascular complications and stroke. In these circumstances code to the primary condition of focus ignoring pathogenesis, but following rules for sequelae where appropriate.

 

Official terminology

Full name of category

Short name Unique ID
Blood Blood

HRCS_HC_01BLO

 

Related external links

International Classification of Diseases (ICD 10 v2016) – Chapter III:   Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

 

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